In this study, it is aimed to evaluate the content of curriculums of the “Management Information Systems (MIS)” departments, whose numbers in Turkish universities are increasing exponentially year by year, and evaluating and discuss, in the light of the findings, how new science fields affect the information management processes. Moreover, the literature is examined and reviewed in order to reveal how the strong connections, differences, and similarities among information-based disciplines are perceived from different perceptive. In addition, the curriculums of some departments in United States (US) universities, which are accepted as the pioneers of MIS departments and have led to widespread of these departments all over the world, are evaluated similarly by using content analysis and compared to those of 43 Turkish universities, when possible, that accept their students by the central university entrance exam. The findings show that MIS science field is quite similar to other information-based/information-oriented fields in terms of their scope and content. It is possible to say that MIS differentiates from other information-based disciplines that MIS is balanced both in technical and social aspects and contains more elements in terms of hardware, software, people and processes. In addition, it is possible to draw some conclusions about the purposes and qualifications of MIS departments’ curriculums in Turkish universities. Moreover, the findings show that the harmony between the purposes and the curriculum contents of MIS departments in the US universities that are relatively well-established ones is not available for those in Turkish universities. At the end of the study, some suggestions are made about how to eliminate this kind of deficiencies and how MIS departments should develop their curriculums in harmony with their purposes.