The aim of this study was to investigate self-esteem and various demographic variables as predictors of psychological resilience. This study, which was designed based on a quantitative research approach, was conducted with 348 university students (female=212, male=136) studying at various programs of Recep Tayyip Erdoğan University and Avrasya University (Psychology, Psychological Counseling, and Guidance, Social Work, Economics, Theology, Sports Management). Two-Dimensional Self-Esteem Scale adapted to Turkish by Doğan (2011) and the Brief Resilience Scale adapted to Turkish by Doğan (2015) were used in the study. The data obtained from the study were analyzed by independent-samples t-test, one-way ANOVA, and multiple regression analysis. As a result of the study, it was determined that self-liking and self-competence, which are the dimensions of self-esteem, explained psychological resilience significantly. Gender, grade level, department, whether the department was in the field of mental health, and the average grade and number of siblings were not significant predictors of psychological resilience.